pSOFA (Pediatric SOFA)
- Category: Organ dysfunction
- Version: v1.1.1
- Reviewed: Reviewed 6 Sep 2026
- Validation: Validation pending
pSOFA total = respiratory + coagulation + hepatic + cardiovascular + neurologic + renal: six organ subscores, each 0–4, summed to 0–24 (Matics & Sanchez-Pinto 2017). Respiratory uses P/F when a PaO₂ exists (≥400 → 0; 300–399 → 1; 200–299 → 2; 100–199 → 3; <100 → 4), otherwise S/F, only at SpO₂ ≤ 97% (≥292 → 0; 264–291 → 1; 221–264 → 2; 148–220 → 3; <148 → 4); an exact 264 resolves to the worse subscore (2), per the worst-value rule. Subscores 3–4 require respiratory support, so a 3/4-band ratio without support is capped at 2; that cap is entailed by the published table, not added here. Coagulation from platelets (×10³/µL): ≥150 → 0; 100–149 → 1; 50–99 → 2; 20–49 → 3; <20 → 4. Hepatic from total bilirubin (mg/dL): <1.2 → 0; 1.2–1.9 → 1; 2.0–5.9 → 2; 6.0–11.9 → 3; ≥12 → 4. Cardiovascular is the worse of the age-banded MAP subscore (0 or 1) and the vasoactive tier: dobutamine any dose or dopamine ≤5 → 2; dopamine >5 or epinephrine ≤0.1 or norepinephrine ≤0.1 → 3; dopamine >15 or epinephrine >0.1 or norepinephrine >0.1 → 4 (µg/kg/min). Neurologic from total GCS: 15 → 0; 13–14 → 1; 10–12 → 2; 6–9 → 3; <6 → 4. Renal from serum creatinine against age-banded cut points. Seven age bands (<1, 1–11, 12–23, 24–59, 60–143, 144–216, >216 months); above 216 months the MAP and creatinine cut points are adult SOFA’s. Missing data scores that organ 0, which is the paper’s own rule that a variable unmeasured in the 24 h window is taken as normal, so a partial entry reads lower than a complete one.
Missing data scores that organ 0. That is the paper’s own rule, a variable unmeasured in the 24 h window taken as normal, so a partial entry reads lower than a complete one. An SpO₂ above 97% with no PaO₂ falls into that trap WITHOUT the field being blank: the ratio is unusable above 97%, so the respiratory subscore is taken as 0 and the total reads lower than the child is. The published S/F table prints 264 in two rows at once, as the lower bound of the subscore-1 row and the upper bound of the subscore-2 row, so the source assigns an exact 264 to both; this calculator resolves it to the worse subscore (2), per the worst-value rule. Subscores 3–4 require respiratory support, and a 3/4-band ratio without support is capped at 2; that cap is entailed by the published table, not added here. What counts as support is undefined in the paper, and this calculator’s reading is that invasive or non-invasive support both qualify, high-flow included. Phoenix contrast, worth stating once: pSOFA attaches its support requirement to the top two respiratory bands, capping an unsupported child at 2, while Phoenix multiplies every tier by a support flag, flooring an unsupported child at 0. The same child at the same ratio can be pSOFA respiratory 2 and Phoenix respiratory 0 simultaneously. Both implement their own instrument correctly; neither should be harmonised to the other. A total above 8 sits above the maximum-pSOFA cut point that best separated survivors from non-survivors in the single-center derivation cohort (AUROC 0.94). That is a statistical association on the encounter maximum, not a treatment threshold. Scope: pSOFA was derived in children 21 years and younger. The <1-month band exists, but neonates were not the derivation population; nSOFA is the score derived for preterm very-low-birth-weight infants. Age input runs to 250 months deliberately, since the cohort ran to 252.
| Result | Interpretation |
|---|---|
| < 9 | 0–8 — At or below the >8 cut point reported by Matics & Sanchez-Pinto (2017). Lower maximum pSOFA was associated with lower observed in-hospital mortality in the single-center derivation cohort. |
| ≥ 9 | >8 — Above the maximum-pSOFA cut point (>8) that best separated survivors from non-survivors in the derivation cohort (AUROC 0.94). This is a statistical association for the encounter maximum, not a treatment threshold. |
References
- Matics TJ, Sanchez-Pinto LN. Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children. JAMA Pediatr. 2017;171(10):e172352.PMID 28783810DOI 10.1001/jamapediatrics.2017.2352
- Vincent JL, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22(7):707-710.Adult SOFA lineage adapted by pSOFA; no adult-SOFA number is used directly here.PMID 8844239DOI 10.1007/BF01709751
- Khemani RG, Patel NR, Bart RD 3rd, Newth CJL. Comparison of the pulse oximetric saturation/fraction of inspired oxygen ratio and the PaO2/fraction of inspired oxygen ratio in children. Chest. 2009;135(3):662-668.Derivation of the SpO₂:FiO₂ ratio, restricted to SpO₂ 80–97% — the origin of the ≤97% ceiling pSOFA's Table 1 footnote applies.PMID 19029434DOI 10.1378/chest.08-2239
- Khemani RG, Thomas NJ, Venkatachalam V, et al. Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury. Crit Care Med. 2012;40(4):1309-1316.Multicentre re-derivation of the SpO₂-based markers over the same SpO₂ 80–97% window.PMID 22202709DOI 10.1097/CCM.0b013e31823bc61b
- Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020;88(1):85-90.nSOFA, the organ-dysfunction score derived FOR neonates (0–15). Named here so the neonatal caveat points somewhere; no nSOFA number is used in this score.PMID 31394566DOI 10.1038/s41390-019-0517-2
Reproduction rights
Freely reproducible.pSOFA is a threshold/formula-based score; numeric cut points and scoring rules are facts, not copyrightable expression (psofa.md IP status). No verbatim scale-item prose is reproduced. The neurologic subscore consumes only the integer GCS total, so no GCS eye/verbal/motor response-descriptor wording is copied into this platform.
Independent clinical validation: pending
Two independent clinical validators will be named here once review is complete.
- 2026-08-10v1.0.0Initial releaseInitial published text.
- 2026-09-03v1.1.0ClarificationSays so when an SpO₂ above 97% is entered with no PaO₂. The SpO₂:FiO₂ ratio saturates above 97%, so the value is accepted and then discarded and the respiratory subscore stays 0 — with the field FILLED, which the form's partial-entry cue cannot see, because it watches for blanks. The number is unchanged; what is new is that the result now says why it is 0 and names the field, beside the subscore and beside the input. Found on 2026-09-03 by an audit of the text-condensing pass, which had removed the one sentence that disclosed it.
- 2026-09-06v1.1.1ClarificationAdded a one-line description for the catalogue card and shortened field guidance to fit an info toggle. No rule, threshold or reference changed.
Other organ dysfunction scores
Important. For use by qualified health professionals as an informational and educational aid. It supports clinical judgment and does not replace it. Verify every result independently before making a clinical decision. This is not a medical device.